Researchers gave MOTS-c to 22-month-old mice (roughly 70 in human years) for two weeks. Their running capacity doubled. These old mice outperformed untreated middle-aged animals. A single injection 10 minutes before exercise increased running time by 12% and distance by 15%.
That study changed how scientists think about aging and exercise. MOTS-c isn’t a drug – it’s a signaling molecule your body already makes, mainly in your muscles during exercise. Levels drop as you age. The research question: what happens when you add it back?






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